Recent Publications from NDRG PIs

1.    Gutama B, Cornely RM, Nemani S, Weikert DR, Wong L, Liu YK, et al. Role of Polyethylene Glycol-Mediated Axonal Fusion in Early Recovery of Median and Ulnar Nerve Injury: A Pilot Double-Blind Randomized Clinical Trial. J Am Coll Surg. 2026 May 1;242(5):1243–57.

2.    Lee JD, Nguyen A, Gibbs CE, Jin ZR, Wang Y, Moghadasi A, et al. Monitoring in real time and far-red imaging of H2O2 dynamics with subcellular resolution. Nat Chem Biol. 2026 Apr;22(4):556–67.

3.    Blum E, Wright DJ, Liu YK, Dy CJ. Current Gaps and Future Directions in Brachial Plexus, Upper-Extremity and Lower-Extremity Nerve Injuries (Nerve SPACE 2025). Journal of Hand Surgery Global Online. 2026 Mar;8(2):100935.

4.    Goldstein AJ, Leahy TP, Mack DL, Sniadecki NJ. Dystrophin loss in engineered heart tissues recapitulates clinically relevant aspects of dystrophic cardiomyopathy. J Biomech Eng. 2026 Feb 1;148(2).

5.    Gerlach Melhedegaard E, Rostedt F, Gineste C, Seaborne RA, Dugdale HF, Belhac V, et al. Myosin inhibition partially rescues the myofiber proteome in X-linked myotubular myopathy. JCI Insight. 2025 Dec 22;10(24).

6.    Williams NP, Beussman KM, Foster JR, Rhodehamel M, Williams CA, Tsui JH, et al. Bioengineered Human Cardiac Ventricular Model with Transmural Helical Remodeling. Adv Healthc Mater. 2025 Aug;14(22):e2502005.

7.    Dy CJ, Antes AL, Baltzer HL, Chim H, Dengler J, Gfrerer L, et al. Development of a core outcomes set for peripheral nerve injury. Journal of Hand Surgery Global Online. 2025 Jul;7(4):100724.

8.    Burgess J, Arora J, Green A, Singh A, Jarman E, Kang A, et al. Establishing a murine model of muscle changes in chronic nerve compression. J Hand Surg Am. 2025 Jun;50(6):685–96.

9.    Crowe CS, Liu YK, Curtin CM, Hentz VR, Kozin SH, Fox IK, et al. Surgical strategies for functional upper extremity reconstruction after spinal cord injury. Muscle Nerve. 2025 May;71(5):802–15.

10.   Seong J, Kim M, Yoo J, Mack DL, Lee JH, Joo J. Sustained Release of HIF-2α Inhibitors Using Biodegradable Porous Silicon Carriers for Enhanced Immunogenic Cell Death of Malignant Merkel Cell Carcinoma. ACS Appl Mater Interfaces. 2025 Feb 5;17(5):7449–61.

11.   Fleming JW, McCloskey MC, Gray K, Nash DR, Leung V, Michas C, et al. An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing. Current Research in Toxicology. 2025 Jan 26;8:100218.

12.   Rybalka E, Park HJ, Nalini A, Baskar D, Polavarapu K, Durmus H, et al. Current insights in ultra-rare adenylosuccinate synthetase 1 myopathy – meeting report on the First Clinical and Scientific Conference. 3 June 2024, National Centre for Advancing Translational Science, Rockville, Maryland, the United States of America. Orphanet J Rare Dis. 2024 Nov 26;19(1):438.

13.   Mair DB, Tsui JH, Higashi T, Koenig P, Dong Z, Chen JF, et al. Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platform. Proc Natl Acad Sci USA. 2024 Oct;121(40):e2404644121.

14.   Slick RA, Sutton J, Haberman M, O’Brien BS, Tinklenberg JA, Mardikar A, et al. High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy. Biol Open. 2024 Sep 15;13(9).

15.   Mozin E, Massouridès E, Mournetas V, Lièvre C, Bourdon A, Jackson DL, et al. Dystrophin deficiency impairs cell junction formation during embryonic myogenesis from pluripotent stem cells. iScience. 2024 Jul 19;27(7):110242.

16.   Chirikian O, Faynus MA, Merk M, Singh Z, Muray C, Pham J, et al. YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes. BioRxiv. 2024 Jun 5;

17.   Lee S, Vander Roest AS, Blair CA, Kao K, Bremner SB, Childers MC, et al. Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration. Proc Natl Acad Sci USA. 2024 May 7;121(19):e2318413121.

18.   Sachdev A, Gill K, Sckaff M, Birk AM, Aladesuyi Arogundade O, Brown KA, et al. Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision. Proc Natl Acad Sci USA. 2024 Apr 23;121(17):e2307814121.

19.   Chun C, Lee JH, Bothwell M, Nghiem P, Smith AST, Mack DL. Human motor neurons elicit pathological hallmarks of ALS and reveal potential biomarkers of the disease in response to prolonged ifnγ exposure. J Neurosci. 2024 Apr 17;44(16).

20.   Mozin E, Massouridès E, Mournetas V, Lièvre C, Bourdon A, Jackson DL, et al. Dystrophin deficiency impairs cell junction formation during embryonic myogenesis. BioRxiv. 2024 Apr 8;

21.   Lee JD, Won W, Kimball K, Wang Y, Yeboah F, Evitts KM, et al. Structure-guided engineering of a fast genetically encoded sensor for real-time H2O2 monitoring. BioRxiv. 2024 Feb 4;

22.   Goldstein AJ, Padgett RM, Bremner SB, Higashi T, Obenaus AM, Bolduan S, et al. Engineered Heart Tissues for Standard 96-Well Tissue Culture Plates. Methods Mol Biol. 2024;2805:89–100.

23.   Gartz M, Haberman M, Sutton J, Slick RA, Luttrell SM, Mack DL, et al. ACTA1 H40Y mutant iPSC-derived skeletal myocytes display mitochondrial defects in an in vitro model of nemaline myopathy. Exp Cell Res. 2023 Mar 15;424(2):113507.

24.   Smith AS, Luttrell SM, Dupont J-B, Gray K, Lih D, Fleming JW, et al. High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing. J Tissue Eng. 2022 Dec;13:20417314221122130.

25.   Bremner SB, Mandrycky CJ, Leonard A, Padgett RM, Levinson AR, Rehn ES, et al. Full-length dystrophin deficiency leads to contractile and calcium transient defects in human engineered heart tissues. J Tissue Eng. 2022 Dec;13:20417314221119628.

26.   Pioner JM, Santini L, Palandri C, Langione M, Grandinetti B, Querceto S, et al. Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency. Front Physiol. 2022 Nov 7;13:1030920.

27.   Smith AST, McCain ML, Bothwell M, Mack DL. Editorial: Modeling neuromuscular diseases to determine molecular drivers of pathology and for drug discovery. Front Cell Dev Biol. 2022 Oct 5;10:1017356.

28.   Childers MC, Regnier M, Bothwell M, Smith AST. Conformational sampling of CMT-2D associated GlyRS mutations. Brain Multiphysics. 2022 Sep 6;3.

29.   Shi Y, Liu G, Wu R, Mack DL, Sun XS, Maxwell J, et al. Differentiation Capacity of Human Urine-Derived Stem Cells to Retain Telomerase Activity. Front Cell Dev Biol. 2022 May 23;10:890574.

30.   Bremner SB, Gaffney KS, Sniadecki NJ, Mack DL. A change of heart: human cardiac tissue engineering as a platform for drug development. Curr Cardiol Rep. 2022 May;24(5):473–86.